Charles V
On 6 May 1527 the unpaid troops of the Holy Roman Emperor, Charles V, defied their leader, the Duke of Bourbon, who was rebelling against François I of France, and sacked Rome. The orgy of vandalism and violence against the inhabitants was worse than anything that had befallen the Holy City since it fell to the Vandals in AD 455. The city was devastated, with as much as half of its population slaughtered or killed by the epidemics which followed. Pope Clement VII was a prisoner, with disastrous results for Henry VIII’s annulment case.
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